The release of drugs with drug delivery systems (DDS) is still not satisfactorily realized.
In the project “gesteuerte Wirkstofffreisetzung“ funded by the Federal Ministry for Economic Affairs and Climate Action, a triggered drug release system is to be developed based on the use of porous fibers filled with active ingredients. The triggering is to be achieved by adding thermoreversible gelling polymers, which release the active ingredient as a result of phase separation when a critical temperature is exceeded. Polymers based on poly-N-isopropylacrylamide (PNIPA) are modified by cross-linking and polymer admixtures so that the switching temperature is in the range of the skin temperature and the release of the active ingredient can be specifically initiated by the application of heat or by heating as a result of inflammation. The properties of the porous fibers are optimally adapted by fiber modification and the release of the active ingredient is tested in detail.
The project creates the basic knowledge for the chemical structure and triggerable release of new DDS. The target groups are medium-sized textile and medical technology companies such as manufacturers of wound dressings and smart textiles as well as manufacturers of porous fibers and polymers.
